http://dcollection.ewha.ac.kr:80 The DSpace digital repository system captures, stores, indexes, preserves, and distributes digital research material. Tue, 04 Aug 2026 17:49:31 GMT 2026-08-04T17:49:31Z https://dspace.ewha.ac.kr/handle/2015.oak/275937 Title: Personalized Smartphone Messaging for Secondary Prevention After Percutaneous Coronary Intervention: Randomized Controlled Trial Ewha Authors: 안정훈 Abstract: Background: Cardiac rehabilitation improves outcomes after percutaneous coronary intervention (PCI), but participation remains suboptimal due to barriers such as distance, cost, and lack of referral. Mobile health interventions may enhance accessibility and engagement. Objective: This study evaluated the effectiveness and user acceptability of a smartphone messaging app (AnSim) in improving cardiovascular risk factors among patients who recently underwent PCI. Methods: A 2-arm randomized controlled trial was conducted at 2 Korean hospitals; 120 patients who had undergone PCI within the prior month were randomized (1:1) to receive AnSim plus usual care (intervention) or usual care alone (control). The intervention comprised personalized messages tailored by behavioral stage and risk profile, delivered 6 times/week for 6 months. Outcomes were assessed at baseline, 6 months, and 9 months. The primary outcome was change in blood pressure (BP) at 6 and 9 months. Secondary outcomes were lipid profiles, hemoglobin A1c, BMI, smoking status, physical activity, and achievement of guideline-recommended risk-factor targets. User acceptability was assessed by questionnaire. Results: Overall, 115 (95.8%; intervention: n=58, control: n=57) participants completed follow-up at 6 months and 110 (91.7%; intervention: n=54, control: n=56) at 9 months. At 6 months, systolic BP was 124.9 (SD 16.7) mmHg in the intervention group and 124.8 (SD 13.1) mmHg in the control group (between-group difference 0.1 mmHg, 95% CI-5.4 to 5.6), and diastolic BP was 80.2 (SD 11.4) mmHg vs 78.4 (SD 10.6) mmHg (difference 1.8 mmHg, 95% CI-2.3 to 5.9). At 9 months, systolic BP was 126 (SD 14.2) mmHg vs 128 (SD 15.4) mmHg (difference-2 mmHg, 95% CI-7.6 to 3.6), and diastolic BP was 80.8 (SD 13.2) mmHg vs 81.3 (SD 12.0) mmHg (difference-0.5 mmHg, 95% CI-5.3 to 4.3). No significant between-group differences were observed in secondary outcomes. In post hoc analyses, participants with above-median message reading were more likely to achieve >= 4 of 5 guideline-recommended risk-factor targets at 9 months (69% vs 19.2%; relative risk 3.59, 95% CI 1.57-8.18; P<.001) and logged more diary entries (mean difference 203.4 entries, 95% CI 79.3-327.5; P=.001). BP responders at 9 months read messages on more days than nonresponders (110.3 vs 83.3 d; mean difference 27 d, 95% CI 4.6-49.3; P=.02). Among survey respondents (54/60, 90%), 87% (47/54) found the messages helpful and 81.4% (44/54) wished to continue. Two events occurred in the control group (P=.50). Conclusions: This trial found no between-group improvement in BP with low-intensity personalized messaging compared to an attention-matched diary app, but exploratory analyses suggest engagement may be a key determinant of potential benefit. Unlike comprehensive app-based cardiac rehabilitation programs, AnSim provides scalable behavioral reinforcement that can be integrated into post-PCI follow-up with minimal burden. These findings support future pragmatic trials optimizing engagement strategies and evaluating longer-term clinical and implementation outcomes. Trial Registration: Clinical Research Information Service (CRIS) KCT0002361; https://cris.nih.go.kr/cris/search/detail-Search.do?seq=7230 Thu, 01 Jan 2026 00:00:00 GMT https://dspace.ewha.ac.kr/handle/2015.oak/275937 2026-01-01T00:00:00Z https://dspace.ewha.ac.kr/handle/2015.oak/275936 Title: SVO70 (Optimal Target Low-Density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke): Rationale and Study Design Ewha Authors: 송태진; 장윤경 Abstract: Background Current stroke guidelines lack subtype-specific recommendations for optimal low-density lipoprotein cholesterol targets. Indeed, most lipid-lowering trials have not differentiated between stroke subtypes or focused primarily on large artery atherosclerosis, leaving a gap in evidence for other stroke subtypes, such as small vessel occlusion stroke. This study is designed to evaluate whether intensive lipid-lowering therapy is superior to standard therapy in reducing major adverse cardiovascular events among patients with small vessel occlusion stroke. Methods SVO70 (Optimal Target Low-Density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke) is a multicenter, prospective, randomized, open, blinded-end point clinical trial in which adult patients with neuroimaging-confirmed small vessel occlusion stroke within 180 days of randomization will be enrolled. Key exclusion criteria include predefined low-density lipoprotein cholesterol targets for other comorbidities, contraindications to statin, and pregnancy or lactation. Eligible participants will be randomized 1:1 to achieve low-density lipoprotein cholesterol <70 mg/dL (intensive group) or 90 to 110 mg/dL (standard group). The trial aims to enroll 4016 participants over a 2-year recruitment period, with a minimum follow-up of 4 years. The primary end point is the occurrence of major adverse cardiovascular events, defined as cardiovascular death, stroke, and acute coronary syndrome, during the follow-up period. Secondary end points include (1) any stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, (4) cardiovascular death, (5) myocardial infarction, (6) all-cause death, and (7) acute coronary syndrome. Conclusions This study will provide valuable information for determining optimal low-density lipoprotein cholesterol targets for patients with small vessel occlusion stroke. Thu, 01 Jan 2026 00:00:00 GMT https://dspace.ewha.ac.kr/handle/2015.oak/275936 2026-01-01T00:00:00Z https://dspace.ewha.ac.kr/handle/2015.oak/275938 Title: Comparison of Highly Cross-Linked and Conventional Polyethylene During Simultaneous Bilateral Cruciate-Retaining Total Knee Arthroplasties Ewha Authors: 김영후; 박장원 Abstract: Background:There have been no long-term studies comparing the revision rates of a highly cross-linked polyethylene (HXLPE) bearing with those of a conventional polyethylene (CP) bearing among cruciate-retaining (CR) total knee arthroplasties (TKAs). The aim of the current long-term study was to compare CR TKAs with HXLPE and CP bearings in terms of clinical, radiographic, and computed tomographic (CT) scan results; prevalence of osteolysis; revision rate; and implant survivorship.Methods:This study enrolled a consecutive series of 410 Korean patients (mean age, 62.6 +/- 8 years) who underwent simultaneous bilateral TKAs during the same anesthetic session. This study included 164 men and 246 women. Each patient underwent a posterior CR high-flexion TKA (NexGen CR-Flex TKA; Zimmer Biomet) with an HXLPE bearing on 1 side and a NexGen CR-Flex TKA with a CP bearing on the opposite side. The mean follow-up period was 17.5 years (range, 15 to 19 years).Results:At the latest follow-up, there were no significant differences between the HXLPE and CP groups with regard to the Knee Society score (94 compared with 93 points), Western Ontario and McMaster Universities Osteoarthritis Index (19.2 points for both groups), range of motion (125 degrees compared with 126 degrees), radiographic and CT results, or revision rate (2.0% compared with 2.2%). No knee showed osteolysis in either group. The estimated survival rate at 17.5 years, using revision or aseptic loosening as the end point, was 98.0% (95% confidence interval, 92% to 100%) for the group with the CR-Flex TKA with an HXLPE bearing and 97.8% (95% confidence interval, 92% to 100%) for the group with the CR-Flex TKA with a CP bearing.Conclusions:The findings of this long-term study (minimum follow-up of 15 years) indicate that CR-Flex TKAs with HXLPE and CP bearings both yielded excellent clinical outcomes and implant survivorship. However, no significant clinical advantage was observed for HXLPE over CP bearings in this patient population.Level of Evidence:Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. Thu, 01 Jan 2026 00:00:00 GMT https://dspace.ewha.ac.kr/handle/2015.oak/275938 2026-01-01T00:00:00Z https://dspace.ewha.ac.kr/handle/2015.oak/275939 Title: Optical probes for bioimaging of tumor-infiltrating immune cells and their applications in cancer immunotherapy Ewha Authors: 윤주영 Abstract: The role of tumor-infiltrating immune cells (TIICs) in the tumor microenvironment (TME) is crucial in tumor development. The precise localization of TIICs within tumor tissues and the elucidation of their biological processes are critical for tumor diagnosis, treatment, and prognosis. Currently, optical probes with high specificity, sensitivity, and spatiotemporal resolution have emerged as powerful tools for the precise localization of TIICs and the investigation of their biological functions. In addition, the modifiability of optical biomaterials with these characteristics enables them to facilitate diverse and precise localization of TIICs and the monitoring of biological processes according to different design strategies. This review summarizes recent advancements in optical probes derived from optical biomaterials, including design strategies for TIIC-targeted optical probes, their applications in precise TIIC localization, and biological process monitoring. Furthermore, we emphasize the importance of their integration with immunotherapy, analyze the underlying factors contributing to the limited development of optical probes for regulatory T cells (Tregs), and systematically discuss the opportunities and challenges associated with their rapid advancement in tumor diagnosis and treatment. Thu, 01 Jan 2026 00:00:00 GMT https://dspace.ewha.ac.kr/handle/2015.oak/275939 2026-01-01T00:00:00Z